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                                                  萬羣教授科研團隊

                                                  發佈日期: 2016-11-14瀏覽次數:

                                                  科研團隊(課題組):蛋白質結構與功能

                                                    負責人(聯繫方式):萬羣  ,qunwan@njau.edu.cn

                                                  研究方向

                                                  1應用結構生物學(X-光衍射和中子衍射)等多種方法研究酶蛋白的催化機理和蛋白質改造 ;

                                                  2)結合虛擬篩選和直接得到晶體結構兩種方式研究靶標蛋白與藥物分子的相互作用 ,篩選和改造現有藥物分子,提高其特異性、親和力、穩定性和跨膜通透性。

                                                  團隊成員:萬羣 教授  ,馬保亮 講師

                                                  課題負責人簡介:萬羣,南京農業大學理學院教授、博士生導師。2008年博士畢業於美國佛蒙特大學分子生理與生物物理專業,曾在美國能源部橡樹嶺國家實驗室、美國凱斯西儲大學藥理系從事博士後的研究工作,後在上海美迪西生物製藥有限公司擔任藥物開發部主任,2015年到南京農業大學理學院工作。在PNASStructureJBCJMB等雜誌發表22篇論文,SCI影響因子總計60 ,並被CellPNASNat Struct Biol等權威雜誌引用超過250次。爲J.Struct Biol,Acta Cryst Sect DPlons OneSci RepSCI雜誌審稿人。

                                                   科研項目:

                                                  國家自然科學基金面上項目,木聚糖酶催化反應機理的研究及耐酸鹼突變體的設計,負責人 萬羣 ,2017-2020 ;

                                                  江蘇省自然科學基金面上項目,應用中子衍射技術研究糖苷水解酶的催化反應機理  ,負責人 萬羣 ,2016-2019 ;

                                                  教育部留學人員科研啓動基金,基於晶體結構的驅動蛋白ATP水解機制的研究和抗癌藥物設計,負責人 萬羣 ,2014-2016 ;

                                                  天然藥物活性組分與藥效國家重點實驗室開放研究基金,作爲二氫葉酸還原酶抑制劑的茶多酚的改性研究,負責人 萬羣 ,2016-2017;

                                                  中央高校科研基本業務費重大專項,基於生物源活性分子先導的新農藥創制——合理設計、合成、生物活性與作用機制研究,參加 ,2016-2019;

                                                  教學工作:大學物理、物理實驗、蛋白質晶體結構與功能(研究生課程)

                                                   代表論文、專利、專著

                                                  Wan Q., Parks J.M., Hanson B.L., Fisher S.Z., Ostermann A., Schrader T.E., Graham D., Coates L., Langan P., Kovalevsky, A. Direct determination of protonation states and visualization of hydrogen bonding in a glycoside hydrolase with neutron crystallography. Proc Natl Acad Sci USA, 112(40): 12384-12389, October 6, 2015 (影響因子:9.6).

                                                  Wan Q., Bennett C.B.,Wilson A.W., Kovalevsky A., Langan P., Howell E., Dealwis C.G. Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh resolution X-ray crystallography. Proc Natl Acad Sci USA, 111(51):18225-18230, Decemer 23, 2014 (影響因子:9.8).

                                                  Wan Q., Zhang Q., Hamilton-Brehm S., Weiss K., Mustyakimov M., Graham D., Coates L., Langan P., Graham D. and Kovalevsky A. X-ray crystallographic studies of family 11 xylanase Michaelis and product complexes: implications for the catalytic mechanism. Acta Cryst D70:11-23. January, 2014 (影響因子:7.2,封面文章).

                                                  Wan Q., Ahmad M. F., Fairman J., Gorzelle B., Fuente M., Dealwis C. G., Maguire M. X-ray Crystallography and Isothermal Titration Calorimetry Studies of Salmonella Znic Transporter ZntB. Structure. 19(5):700-710. May 2011.(影響因子:6.3

                                                  Miyagi M., Wan, Q.(並列第一作者), Ahmad M. F., Gokulrangan G., Tomechko S. E., Bennett B., Dealwis C. G. Histidine Hydrogen-Deuterium Exchange Mass Spectrometry for Probing the Microenvironment of Histidine Residues in Dihydrofolate Reductase. PLoS One. 6(2): e17055. February 2011.(影響因子:4.3

                                                  Bennett B. C., Wan Q.(並列第一作者), Ahmad M. F., Dealwis C. G. X-ray structure of the ternary MTX·NADPH complex of the anthrax dihydrofolate reductase: A pharmacophore for dual-site inhibitor design. J. Struct. Biol 166(2): 162-171. May 2009.(影響因子:3.7

                                                  Ahmad M. F., Wan Q. (並列第一作者), Jha, S., Motea, E., Berdis, A., Dealwis C.G. Evaluating the Therapeutic Potential of a Non-Natural Nucleotide that Inhibits Human Ribonucleotide Reductase. Molecular Cancer Therapeutics. August 28, 2012; 11(10):2077-2086 (影響因子:5.1)

                                                  Wijerathna, S.R., Ahmad M. F., Xu, H., Fairman J, Zhang, J., Kaushal, P.S., Wan, Q., Kiser, J.Y., and Dealwis, C.G. Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy. Pharmaceuticals. 2011, 4(10), 1328-1354. (影響因子:3.2

                                                  Ahmad M.F., Kaushal P.S., Wan Q., Wijerathna S.R., An X., Huang M., Dealwis C.G. Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J. Mol. Biol 419(5): 315-29. March 2012. (影響因子:4.1)

                                                  Nair U. B, Joel P. B, Wan Q., Lowey S., Rould M. A, Trybus K. M. Crystal Structures of Monomeric Actin bound to Cytochalasin D. J. Mol. Biol., 384(4):848-864. October 2008.(影響因子:4.1

                                                  Rould M. A., Wan Q., Joel P. B, Lowey S., Trybus K. M. Crystal structures of expressed non-polymerizable monomeric actin in the ADP and ATP states. J. Biol. Chem., 28142: 31909-31919. August 2006.(影響因子:5.8